PGT-M (Preimplantation Genetic Testing for Monogenic or Single Gene Defects)

Reprogene helps couples deliver a healthy pregnancy without worrying about increased risks of genetic diseases

PGT-M is a specific test that detect single gene disorders by determines which of the embryos are out of risk and safe for embryo transfer. It is done before the pregnancy to help avoid difficult situations and outcomes. If there is a well-known history of genetic diseases that runs in the family, It is Highly

recommended that you conduct a PGT-M test. Some conditions can be inherited from either parent, either through an autosomal dominant manner (in which one parent is affected) or an autosomal recessive manner (in which it is inherited from both the unaffected carrier). Some conditions are sex linked so only the father or mother can carry them. However, not all diseases are caused by single gene mutations and fall out of the scope of PGT-M. reprogene offers PGT-M for identified mutation in genetic diseases. We use state-of-the-art technologies for PGT-M, using multiple detection methods to ensure highly reliable results. All PGT-M tests must be coordinated in advance with reprogene genetic services.

What to expect When requesting a PGT-M Test

Reprogene will need to review the genetic report to determine if we can conduct the PGT-M test. If so, we will require blood samples from the couple and possibly other family members. A specialized probe is designed and customized for each identified mutation. The specialized probe is then used on the embryos to look for any genetic abnormalities. The genetic report with the test results is provided to the IVF clinic for interpretation